WebNeurokinin-1 RA prophylaxis for carboplatin AUC ≥ 4 remains low and largely unchanged despite National Comprehensive Cancer Network and ASCO 2024 recommendations for … WebDec 1, 2024 · Purpose: We aimed to evaluate the performance of therapeutic drug monitoring (TDM) approach in controlling interpatient variability of carboplatin exposure (AUC) in patients treated with TI-CE high-dose chemotherapy for advanced germ cell tumors and to assess the possibility of using a formula-based dosing method as a …
Efficacy and Safety of First-line Single-Agent Carboplatin …
WebThe carbo calculator can be used to find Carboplatin dose (mg) for patients. Now we know the GFR value of the patients using the target AUC which is around 7 mg/ml/min, we can … WebCarboplatin dosage is calculated by using the estimated glomerular filtration rate (GFR) to achieve a target plasma area under the plasma concentration–time curve (AUC). The aims of the present study were to … old stone church brattleboro vt
Ovarian Cancer Treatment Regimens - Cancer Therapy Advisor
WebJun 8, 2024 · Calvert Formula for Carboplatin Dosing: total dose (mg) = target AUC (in mg/mL per min) × [GFR (in mL/min) + 25] A target AUC of 5 (range: 4–6) mg/mL per minute appears to provide the most appropriate dosage range for use of carboplatin alone in patients previously treated with chemotherapeutic agents. WebBecause carboplatin clearance depends largely on GFR, the carboplatin dose needed to achieve a target AUC has historically been calculated starting with an assessment of … WebMar 15, 2024 · Results: A total of 76 patients were identified (median age 49 years). A total of 47 received weekly carboplatin, of whom 83% received at least 11 of 12 planned doses, and 29 received every 3-week carboplatin, of whom 90% received all 4 planned doses. pCR rates were similar, 53% with weekly and 55% with every 3-week carboplatin dosing. isa boulder net a porter