WebJan 20, 2012 · When autophagy was inhibited by beclin-1 and Atg5 knockdown, apoptosis increased, which suggests that autophagy acts as cytoprotective mechanism against UV-induced DNA damage. To our surprise, ATR phosphorylation was only correlated with early LC3B-II expression, which indicates that the protective autophagy at late stages when … WebDec 16, 2012 · Autophagy has attracted attentions as a novel mechanism for tumor development. In this study Human ovarian carcinoma cell line SKOV3 and multidrug-resistant phenotype SKVCR cells were used and the roles of autophagy in radiation-induced cell death were analyzed. Cell viability was examined by colony formation and …
Caspase involvement in autophagy Cell Death
WebSep 7, 2011 · The role of autophagy and its regulation in cancer cells continues to emerge, and studies aim to define optimal strategies to modulate autophagy for therapeutic advantage. ... In addition to the cytoprotective function of autophagy, which is supported by abundant evidence, induction of autophagic cell death has been proposed as a … WebApr 6, 2012 · A cytoprotective role of autophagy is implicated in kidney injury, and we demonstrate that low-dose carbon monoxide, shown to exert cytoprotection against renal fibrosis, induces autophagy to suppress accumulation of Col-I induced by TGF-β1. We also show that TGF-β1 induces autophagy in MMC via TAK1-MKK3-p38 signaling pathway. list of all saw movies in order
Cytoprotection - Wikipedia
WebApr 14, 2024 · Besides that, autophagy has roles in immune responses and inflammation [40,41,42,43]. As such, the maintenance of cellular integrity and defense against … WebNational Center for Biotechnology Information WebApr 7, 2024 · The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including … images of knoebels grove tickets