WebFeb 6, 2024 · In December 2024, Eisai began a Phase 1 trial testing the safety and tolerability of a single intravenous infusion in healthy adults. Secondary outcomes included serum and CSF pharmacokinetics and immunogenicity. An exploratory outcome assessed target engagement by antibody binding to tau protein fragments in the CSF. WebTau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer's disease (AD). Most of tau in CSF is present as fragments.
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WebMar 28, 2024 · Tau is a multifunctional microtubule-associated protein in the neuron. For decades, tau’s main function in neurons has been broadly accepted as stabilizing microtubules in the axon; however, this conclusion was reached mainly on the basis of studies performed in vitro and on ectopic expression of tau in non-neuronal cells. WebThe goals of transurethral resection of bladder tumour (TURBT) are to identify and eradicate visualized bladder tumour if technically safe and feasible and to obtain a specimen of satisfactory quality to enable accurate histological diagnosis. In the setting of high grade bladder tumour this general … Web2024. Issue 99 – Winter 2024/2024 (En Español) Issue 98 – Fall 2024 (En Español) Issue 97 – Spring 2024 (En Español) 2024. Issue 96 – Winter 2024/2024 ... The TAU-USA, a … j and r steakhouse medford ny